College football Week 12 predictions, picks, betting odds for today's Top 25 games
- - College football Week 12 predictions, picks, betting odds for today's Top 25 games
Ehsan Kassim, USA TODAY November 15, 2025 at 6:53 PM
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College football Week 12 predictions, picks, betting odds for today's Top 25 games
Week 12 of the 2025 college football season could provide a chance for a major shakeup of the College Football Playoff field.
Of the 25 ranked teams in the US LBM Coaches Poll, 23 of them will be in action this weekend, including a grand total of two top-10 matchups in the SEC that could shake up the entire 12-team field. No. 4 Alabama (8-1, 6-0 SEC) takes on No. 10 Oklahoma (7-2, 3-2), while No. 5 Georgia (8-1, 6-1) faces off against No. 10 Texas (7-2, 4-1).
US LBM COACHES POLL: College football rankings shuffled as Oklahoma, Texas rise
Another key matchup will be No. 9 Notre Dame vs. No. 23 Pittsburgh, which has drawn enough attention for ESPN's "College GameDay" to return to Pittsburgh for the first time in 20 years.
As has been the case all season, any team could be on upset alert on any given Saturday. Penn State nearly knocked off No. 2 Indiana last week, while No. 14 Vanderbilt avoided an upset at the hands of Auburn in overtime.
Here is an early look at picks, predictions and odds for all of Saturday's Week 12 games on the 2025 college football schedule:
1 / 36Here are some of the funniest signs from ESPN College GameDay this seasonTexas Tech fans await the start of ESPN's College GameDay pregame show, Saturday, Nov. 8, 2025, at Jones AT&T Stadium.College football Week 12 game predictions, picks
Odds courtesy of BetMGM as of Sunday, Nov. 9
No. 1 Ohio State vs UCLA -
Date: Saturday, Nov. 15
Time: 7:30 p.m. ET
Location: Ohio Stadium (Columbus, Ohio)
Spread: Ohio State -31.5
Prediction: Ohio State 42, UCLA 10No. 2 Indiana vs Wisconsin -
Date: Saturday, Nov. 15
Time: 12 p.m. ET
Location: Memorial Stadium (Bloomington, Indiana)
Spread: Indiana -30.5
Prediction: Indiana 38, Wisconsin 10No. 3 Texas A&M vs South Carolina -
Date: Saturday, Nov. 15
Time: Noon ET
Location: Kyle Field (College Station, Texas)
Spread: Texas A&M -18.5
Prediction: Texas A&M 34, South Carolina 16No. 4 Alabama vs No. 10 Oklahoma -
Date: Saturday, Nov. 15
Time: 3:30 p.m. ET
Location: Bryant-Denny Stadium (Tuscaloosa, Alabama)
Spread: Alabama -7
Prediction: Alabama 30, Oklahoma 28No. 5 Georgia vs No. 10 Texas -
Date: Saturday, Nov. 15
Time: 7:30 p.m. ET
Location: Sanford Stadium (Athens, Georgia)
Spread: Georgia -6
Prediction: Georgia 31, Texas 24No. 7 Ole Miss vs Florida -
Date: Saturday, Nov. 15
Time: 7 p.m. ET
Location: Vaught-Hemingway Stadium (Oxford, Mississippi)
Spread: Ole Miss -13.5
Prediction: Ole Miss 42, Florida 17No. 8 Texas Tech vs Central Florida -
Date: Saturday, Nov. 15
Time: 3:30 p.m. ET
Location: Jones AT&T Stadium (Lubbock, Texas)
Spread: Texas Tech -23.5
Prediction: Texas Tech 34, UCF 14No. 9 Notre Dame vs No. 23 Pittsburgh -
Date: Saturday, Nov. 15
Time: Noon ET
Location: Acrisure Stadium (Pittsburgh, Pennslyvannia)
Spread: Notre Dame -10.5
Prediction: Pittsburgh 34, Notre Dame 30No. 12 Georgia Tech vs Boston College -
Date: Saturday, Nov. 15
Time: 3:30 p.m. ET
Location: Alumni Stadium (Chestnut Hill, Massachutsetts)
Spread: Georgia Tech -16.5
Prediction: Georgia Tech 49, Boston College 14No. 12 BYU vs TCU -
Date: Saturday, Nov. 15
Time: 10:15 p.m. ET
Location: LaVell Edwards Stadium (Provo, Utah)
Spread: BYU -5.5
Prediction: TCU 28, BYU 21No. 15 Utah vs Baylor -
Date: Saturday, Nov. 15
Time: 7 p.m. ET
Location: McLane Stadium (Waco, Texas)
Spread: Utah -8.5
Prediction: Utah 30, Baylor 28No. 16 Miami vs NC State -
Date: Saturday, Nov. 15
Time: 7:30 p.m. ET
Location: Hard Rock Stadium (Miami Gardens, Florida)
Spread: Miami -14.5
Prediction: Miami 31, NC State 18No. 17 Michigan vs Northwestern -
Date: Saturday, Nov. 15
Time: Noon ET
Location: Wrigley Field (Chicago)
Spread: Michigan -10
Prediction: Northwestern 23, Michigan 20No. 18 Southern California vs Iowa -
Date: Saturday, Nov. 15
Time: 3:30 p.m. ET
Location: Los Angeles Memorial Coliseum (Los Angeles)
Spread: USC -6.5
Prediction: Iowa 30, USC 24No. 19 Virginia vs Duke -
Date: Saturday, Nov. 15
Time: 3:30 p.m. ET
Location: Wallace Wade Stadium (Durham, North Carolina)
Spread: Duke -6.5
Prediction: Duke 27, Virginia 21No. 20 Tennessee vs New Mexico State -
Date: Saturday, Nov. 15
Time: 4:15 p.m. ET
Location: Neyland Stadium (Knoxville, Tennessee)
Spread: Tennessee -38.5
Prediction: Tennessee 49, New Mexico State 14No. 22 Cincinnati vs Arizona -
Date: Saturday, Nov. 15
Time: Noon ET
Location: Nippert Stadium (Cincinnati, Ohio)
Spread: Cincinnati -6
Prediction: Cincinnati 34, Arizona 31No. 24 Missouri vs Mississippi State -
Date: Saturday, Nov. 15
Time: 7:45 p.m. ET
Location: Memorial Stadium (Columbia, Missouri)
Spread: Missouri -6.5
Prediction: Missouri 30, Mississippi State 20No. 25 James Madison vs App State -
Date: Saturday, Nov. 15
Time: 3:30 p.m. ET
Location: Bridgeforth Stadium (Harrisonburg, Virginia)
Spread: James Madison -20.5
Prediction: James Madison 35, App State 14
This article originally appeared on USA TODAY: College football Week 12 predictions, betting odds, today's schedule
Source: “AOL Sports”
